NexBook L, with Levosulpiride as its active ingredient, exerts its prokinetic effects by blocking dopamine receptors and activating serotonin receptors. This dual action leads to an increased release of acetylcholine, which, in turn, enhances GI peristalsis and raises lower esophageal sphincter pressure, ultimately preventing reflux of GI contents and promoting normal digestive function.
Mode Of Action:
Levosulpiride, found in NexBook L, operates through a dual mechanism of action, employing both dopamine receptor blockade and serotonin receptor agonism.
Dopamine (D2) Receptor Blockade: Levosulpiride blocks enteric dopamine (D2) receptors, both neuronal and muscular. By inhibiting dopamine receptors, Levosulpiride reduces the inhibitory signals in the gastrointestinal (GI) tract. Dopamine typically exerts inhibitory control, and by blocking its receptors, Levosulpiride enhances the release of acetylcholine.
Serotonin (5-HT4) Receptor Agonism: Levosulpiride acts as an agonist at serotonin (5-HT4) receptors. Stimulation of serotonin receptors, specifically the 5-HT4 subtype, further enhances the release of acetylcholine in the GI tract.
Indications:
Foe the treatment of
Dosage:
One capsule daily as prescribed by physician.
Instructions for usage:
- As directed by physician
STORAGE:
Store at a temperature below 30°C in dry place. Keep out of reach of children.
Contraindications:
Pregnancy & lactation.
Known hypersensitivity to esomeprazole, any ingredient in the formulation, or other substituted benzimidazoles
FAQ’s:
NexBook L is generally prescribed for the treatment of specific conditions, and its long-term use should be discussed with a healthcare professional. It is not habit-forming, and the recommended dosage as per physician guidance ensures safe usage.
Yes, NexBook L is indicated for the treatment of Diabetic Gastroparesis, making it a valuable option for individuals dealing with gastrointestinal issues related to diabetes.
NexBook L is available in a tablet form and conveniently packaged in 10 x 10 tablets. This packaging ensures ease of use and portability, making it a practical choice for individuals incorporating it into their daily routine.
