Each hard gelatin capsule houses a powerful duo:
1. Esomeprazole (as enteric-coated pellets) 40 mg: Derived from Esomeprazole magnesium trihydrate IP, this component takes center stage in controlling gastric acid. The enteric coating ensures precise delivery, allowing Esomeprazole to exert its effects where they are needed most.
2. Domperidone (as sustained release pellets) IP 30 mg: Working with Esomeprazole, Domperidone provides sustained relief from associated symptoms like nausea. The sustained release pellets ensure a prolonged effect, addressing not only the root cause but also the discomfort that often accompanies GERD.
Mode Of Action:
NexBook RD operates through a dual-action mechanism, harnessing the synergistic effects of Esomeprazole and Domperidone for comprehensive relief from GERD symptoms.
Esomeprazole – Acid Control Master: Esomeprazole, a potent proton pump inhibitor (PPI), plays a pivotal role in acid suppression. It inhibits the proton pump in the parietal cells of the stomach lining, reducing the secretion of gastric acid. Notably, Esomeprazole exhibits a longer duration of action compared to other PPIs, maintaining intragastric pH above 4 for 24 hours. Its higher potency in acid inhibition ensures robust control over acid reflux, a key contributor to GERD symptoms.
Domperidone – Prokinetic Powerhouse:Domperidone, an active prokinetic agent, complements Esomeprazole’s acid-suppressing capabilities by enhancing gastrointestinal motility. It achieves this through multiple actions:
Increased Smooth Muscle Tone: Domperidone boosts the tone of smooth muscles in the esophagus, thereby reducing esophageal reflux.
Elevation of Lower Esophageal Pressure: By increasing lower esophageal pressure, Domperidone further mitigates the risk of reflux episodes.
Stimulation of Antral Motility: The stimulation of antral motility promotes efficient gastric emptying and restores peristalsis, contributing to improved digestive function.
Anti-Emetic Action for Symptom Control:Domperidone’s additional anti-emetic action plays a crucial role in enhancing symptom control in GERD. By curbing nausea and reducing the likelihood of regurgitation, it contributes to an overall improved quality of life for individuals dealing with GERD-related discomfort.
Indications:
- Gastroesophageal Reflux (GERD)
- Erosive Esophagitis
- NSAID-associated gastropathies
- H-Pylori eradication
- Symptomatic GERD (heartburn) in patients
- Nausea
Dosage:
One capsule daily as prescribed by physician.
Instructions for usage:
- As directed by physician
STORAGE:
Store at a temperature below 30°C in dry place. Keep out of reach of children.
Contraindications:
Pregnancy & lactation.
Known hypersensitivity to esomeprazole, any ingredient in the formulation, or other substituted benzimidazoles
FAQ’s:
No, NexBook RD is contraindicated during pregnancy and lactation due to potential risks. It’s essential to consult a healthcare professional for alternative options in such cases.
Yes, NexBook RD is indicated for various conditions, including erosive esophagitis, NSAID-associated gastropathies, H-Pylori eradication, symptomatic GERD (heartburn), and nausea.
NexBook RD not only controls gastric acid but also addresses associated symptoms like nausea. The combination of Esomeprazole and Domperidone provides comprehensive relief, contributing to an overall improved quality of life for individuals dealing with GERD-related discomfort.
NexBook RD contains Esomeprazole, which helps create an environment unfavorable for H-Pylori growth by controlling gastric acid. This is complemented by Domperidone, which aids in relieving nausea associated with H-Pylori infection.
