By selectively targeting COX-2 and minimizing interference with COX-1, Etoricoxib helps to alleviate pain and inflammation associated with arthritis and ankylosing spondylitis, offering a therapeutic option with potentially fewer gastrointestinal complications compared to non-selective NSAIDs.
Etoricoxib, a distinguished nonsteroidal anti-inflammatory drug (NSAID), orchestrates its mode of action by selectively inhibiting the COX-2 enzyme. This enzyme, central to the production of prostaglandins involved in inflammation and pain, is specifically targeted to provide efficient relief in arthritis and ankylosing spondylitis.
Mode Of Action:
Etoricoxib, a nonsteroidal anti-inflammatory drug (NSAID), exerts its mode of action in the treatment of arthritis and ankylosing spondylitis primarily through its selective inhibition of the cyclooxygenase-2 (COX-2) enzyme. COX-2 is an enzyme involved in the production of prostaglandins, which play a role in inflammation and pain.
1. High Selectivity for COX-2:
Etoricoxib is highly selective for the COX-2 enzyme. This selectivity means that it predominantly inhibits the activity of COX-2, which is involved in the inflammatory response.
2. 100-Fold More Selective for COX-2 than COX-1:
Etoricoxib exhibits a remarkable degree of selectivity for COX-2 over COX-1, with a 100-fold preference for inhibiting COX-2. This selectivity is advantageous as it allows for targeted suppression of inflammation while minimizing potential adverse effects associated with the inhibition of COX-1, which plays a role in maintaining the protective lining of the stomach.
Salient Features:
- Well absorbed from GI tract
- 100% Oral Bioavailability
- Fewer gastrointestinal complications compared to non-selective NSAIDs
Indications:
- Ankylosing spondylitis
- Pain associated to Ankylosing spondylitis
- Osteoarthritis
- Acute Gouty Arthtitis
Dosage:
Once daily or as prescribed by physician
Instructions for usage:
As directed by physician
STORAGE:
Store at a temperature below 30°C in dry place. Keep out of reach of children.
Contraindications:
- Pregnancy & lactation.
- Congestive heart failure.
- Active peptic ulceration.
Disclaimer:
It is important for individuals to use Etoricoxib under the guidance of a healthcare professional and to be aware of potential side effects and contraindications.
FAQ’s:
Yes, Ticobon 90 is indicated for ankylosing spondylitis, offering relief from both the condition itself and the associated pain.
Yes, individuals should be aware of contraindications, such as pregnancy, lactation, congestive heart failure, and active peptic ulceration. Consulting with a healthcare professional is crucial for proper guidance and awareness of potential side effects.
Proper storage below 30°C in a dry place and tightly replacing the cap after each use helps maintain the stability and effectiveness of Ticobon 90, ensuring its therapeutic properties are preserved.
Ticobon 90 is indicated for acute Gouty Arthritis, offering a comprehensive solution for individuals experiencing pain associated with this condition.
Ticobon 90 is designed for once-daily use, with a focus on patient safety through the high selectivity of Etoricoxib, potentially minimizing gastrointestinal complications. However, long-term use should be under the guidance of a healthcare professional.
