The combination of Etoricoxib and Thiocolchicoside in Ticobon MR offers a dual mechanism of action. Etoricoxib addresses inflammation by selectively inhibiting COX-2 and reducing prostaglandin production, while Thiocolchicoside focuses on muscle relaxation through its selective binding to GABA-A receptors and inhibition of glycine receptors. Together, these actions provide comprehensive relief for musculoskeletal pain and associated symptoms.
Mode Of Action:
Ticobon MR is a medication formulated to address musculoskeletal discomfort through its combination of two key active ingredients: Etoricoxib and Thiocolchicoside.
Etoricoxib (60mg):
Etoricoxib is classified as a COX-2 selective inhibitor, meaning it selectively targets isoform 2 of the cyclo-oxygenase enzyme (COX-2). By doing so, Etoricoxib plays a crucial role in modulating the inflammatory response. Specifically, it inhibits the production of prostaglandins (PGs) from arachidonic acid. Prostaglandins are lipid compounds involved in the mediation of inflammation, pain, and fever. By reducing their generation, Etoricoxib helps mitigate inflammation and alleviate associated symptoms.
Thiocolchicoside (4mg):
Thiocolchicoside acts as a centrally acting muscle relaxant with additional neurochemical actions. It mimics the action of gamma-aminobutyric acid (GABA) neurotransmitters and exhibits glycinergic effects. As a competitive GABAA receptor antagonist, Thiocolchicoside enhances the inhibitory actions of GABA, leading to muscle relaxation. Moreover, it inhibits glycine receptors, contributing to its muscle relaxant properties.
Salient Features:
- Well absorbed from GI tract
- Approximately 25% Oral Bioavailability
- Fewer gastrointestinal complications compared to non-selective NSAIDs
Indications:
Dosage:
Twice daily or as prescribed by physician
Instructions for usage:
As directed by physician
STORAGE:
Store at a temperature below 30°C in dry place. Keep out of reach of children.
Contraindications:
- Pregnancy & lactation.
- Congestive heart failure.
- Active peptic ulceration.
Disclaimer:
It is important for individuals to use Etoricoxib under the guidance of a healthcare professional and to be aware of potential side effects and contraindications.
FAQ’s:
It is advisable to maintain hydration and follow a balanced diet which may contribute to overall well-being.
Ticobon MR is primarily indicated for relief from acute pain, lower back pain, and muscle spasms. Consult with a healthcare professional for appropriate recommendations for chronic pain management.
The dosage for Ticobon MR should be adjusted as per the physician’s guidance, taking into consideration individual health conditions, especially in elderly patients.
Etoricoxib’s COX-2 selective inhibition in Ticobon MR is associated with fewer gastrointestinal complications compared to non-selective NSAIDs.
The onset of relief may vary among individuals. Consult with a healthcare professional for personalized information on the expected timeframe for symptom relief.
Ticobon MR combines the anti-inflammatory properties of Etoricoxib with the muscle relaxant effects of Thiocolchicoside, providing a dual mechanism for comprehensive relief from musculoskeletal pain.
